The higher level of organization of the oxidative phosphorylation system

Mitochondrial supercomplexes

authored by

Natalya V. Dudkina, Stephanie Sunderhaus, Egbert J. Boekema, Hans Peter Braun

Abstract

The organization of the oxidative phosphorylation (OXPHOS) system within the inner mitochondrial membrane appears to be far more complicated than previously thought. In particular, the individual protein complexes of the OXPHOS system (complexes I to V) were found to specifically interact forming defined supramolecular structures. Blue-native polyacrylamide gel electrophoresis and single particle electron microscopy proved to be especially valuable in studying the so-called "respiratory supercomplexes". Based on these procedures, increasing evidence was presented supporting a "solid state" organization of the OXPHOS system. Here, we summarize results on the formation, organisation and function of the various types of mitochondrial OXPHOS supercomplexes.

Organisation(s)

Institute of Plant Genetics

External Organisation(s)

University of Groningen

Type

Review article

Journal

Journal of Bioenergetics and Biomembranes

Volume

40

Pages

419-424

No. of pages

6

ISSN

0145-479X

Publication date

07.10.2008

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Physiology, Cell Biology

Electronic version(s)

https://doi.org/10.1007/s10863-008-9167-5 (Access: Open)
https://doi.org/10.15488/11690 (Access: Open)