The higher level of organization of the oxidative phosphorylation system

Mitochondrial supercomplexes

verfasst von

Natalya V. Dudkina, Stephanie Sunderhaus, Egbert J. Boekema, Hans Peter Braun

Abstract

The organization of the oxidative phosphorylation (OXPHOS) system within the inner mitochondrial membrane appears to be far more complicated than previously thought. In particular, the individual protein complexes of the OXPHOS system (complexes I to V) were found to specifically interact forming defined supramolecular structures. Blue-native polyacrylamide gel electrophoresis and single particle electron microscopy proved to be especially valuable in studying the so-called "respiratory supercomplexes". Based on these procedures, increasing evidence was presented supporting a "solid state" organization of the OXPHOS system. Here, we summarize results on the formation, organisation and function of the various types of mitochondrial OXPHOS supercomplexes.

Organisationseinheit(en)

Institut für Pflanzengenetik

Externe Organisation(en)

Reichsuniversität Groningen

Typ

Übersichtsarbeit

Journal

Journal of Bioenergetics and Biomembranes

Band

40

Seiten

419-424

Anzahl der Seiten

6

ISSN

0145-479X

Publikationsdatum

07.10.2008

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Physiologie, Zellbiologie

Elektronische Version(en)

https://doi.org/10.1007/s10863-008-9167-5 (Zugang: Offen)
https://doi.org/10.15488/11690 (Zugang: Offen)