How c-di-GMP controls progression through the Streptomyces life cycle
- authored by
- Kelley A. Gallagher, Natalia Tschowri, Richard G. Brennan, Maria A. Schumacher, Mark J. Buttner
- Abstract
Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3′, 5′-cyclic diguanylic acid (c-di-GMP). So far, three proteins that are directly controlled by c-di-GMP in Streptomyces have been functionally and structurally characterized: the key developmental regulators BldD and σWhiG, and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σWhiG, respectively, to control the two most dramatic transitions of the Streptomyces life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.
- Organisation(s)
-
Institute of Microbiology
- External Organisation(s)
-
Cornell University
Duke University
John Innes Centre
- Type
- Review article
- Journal
- Current opinion in microbiology
- Volume
- 80
- No. of pages
- 10
- ISSN
- 1369-5274
- Publication date
- 08.2024
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Microbiology, Microbiology (medical), Infectious Diseases
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Electronic version(s)
-
https://doi.org/10.1016/j.mib.2024.102516 (Access:
Open)
