How c-di-GMP controls progression through the Streptomyces life cycle
- verfasst von
- Kelley A. Gallagher, Natalia Tschowri, Richard G. Brennan, Maria A. Schumacher, Mark J. Buttner
- Abstract
Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3′, 5′-cyclic diguanylic acid (c-di-GMP). So far, three proteins that are directly controlled by c-di-GMP in Streptomyces have been functionally and structurally characterized: the key developmental regulators BldD and σWhiG, and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σWhiG, respectively, to control the two most dramatic transitions of the Streptomyces life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.
- Organisationseinheit(en)
-
Institut für Mikrobiologie
- Externe Organisation(en)
-
Cornell University
Duke University
John Innes Centre
- Typ
- Übersichtsarbeit
- Journal
- Current opinion in microbiology
- Band
- 80
- Anzahl der Seiten
- 10
- ISSN
- 1369-5274
- Publikationsdatum
- 08.2024
- Publikationsstatus
- Veröffentlicht
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Mikrobiologie, Mikrobiologie (medizinisch), Infektionskrankheiten
- Ziele für nachhaltige Entwicklung
- SDG 3 – Gute Gesundheit und Wohlergehen
- Elektronische Version(en)
-
https://doi.org/10.1016/j.mib.2024.102516 (Zugang:
Offen)
