Structure and function of mitochondrial supercomplexes

authored by

Natalya V. Dudkina, Roman Kouřil, Katrin Peters, Hans Peter Braun, Egbert J. Boekema

Abstract

The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I, III and IV and in a dimeric form of complex V, between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed.

Organisation(s)

Institute of Plant Genetics

External Organisation(s)

University of Groningen

Type

Review article

Journal

Biochimica et Biophysica Acta - Bioenergetics

Volume

1797

Pages

664-670

No. of pages

7

ISSN

0005-2728

Publication date

28.12.2010

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Biophysics, Biochemistry, Cell Biology

Electronic version(s)

https://doi.org/10.1016/j.bbabio.2009.12.013 (Access: Open)