Structure and function of mitochondrial supercomplexes

verfasst von

Natalya V. Dudkina, Roman Kouřil, Katrin Peters, Hans Peter Braun, Egbert J. Boekema

Abstract

The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I, III and IV and in a dimeric form of complex V, between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed.

Organisationseinheit(en)

Institut für Pflanzengenetik

Externe Organisation(en)

Reichsuniversität Groningen

Typ

Übersichtsarbeit

Journal

Biochimica et Biophysica Acta - Bioenergetics

Band

1797

Seiten

664-670

Anzahl der Seiten

7

ISSN

0005-2728

Publikationsdatum

28.12.2010

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Biophysik, Biochemie, Zellbiologie

Elektronische Version(en)

https://doi.org/10.1016/j.bbabio.2009.12.013 (Zugang: Offen)