The life of plant mitochondrial complex I

authored by

Hans Peter Braun, Stefan Binder, Axel Brennicke, Holger Eubel, Alisdair R. Fernie, Iris Finkemeier, Jennifer Klodmann, Ann Christine König, Kristina Kühn, Etienne Meyer, Toshihiro Obata, Markus Schwarzländer, Mizuki Takenaka, Anja Zehrmann

Abstract

The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system.

Organisation(s)

Institute of Plant Genetics
Section Plant Molecular Biology and Plant Proteomics

External Organisation(s)

Ulm University
Max Planck Institute of Molecular Plant Physiology (MPI-MP)
Ludwig-Maximilians-Universität München (LMU)
Humboldt-Universität zu Berlin (HU Berlin)
University of Bonn

Type

Article

Journal

MITOCHONDRION

Volume

19

Pages

295-313

No. of pages

19

ISSN

1567-7249

Publication date

21.02.2014

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Molecular Medicine, Molecular Biology, Cell Biology

Electronic version(s)

https://doi.org/10.15488/11656 (Access: Open)
https://doi.org/10.1016/j.mito.2014.02.006 (Access: Closed)