The mitochondrial processing peptidase

authored by

Hans-Peter Braun, Udo Schmitz

Abstract

The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import. It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle. In mammals and yeast the enzyme is localized in the mitochondrial matrix while in plants it is integrated into a protein complex of the respiratory chain. As the activity of MPP is essential for the viability of eukaryotic cells it is conceivable that inhibitors of MPP which are specific for the soluble enzyme only present in fungi and animals may work as fungicides or insecticides.

Organisation(s)

Section Plant Molecular Biology and Plant Proteomics

Type

Article

Journal

International Journal of Biochemistry and Cell Biology

Volume

29

Pages

1043-1045

No. of pages

3

ISSN

1357-2725

Publication date

1997

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Biochemistry, Cell Biology

Electronic version(s)

https://doi.org/10.1016/S1357-2725(97)00032-0 (Access: Unknown)