The mitochondrial processing peptidase

verfasst von

Hans-Peter Braun, Udo Schmitz

Abstract

The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import. It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle. In mammals and yeast the enzyme is localized in the mitochondrial matrix while in plants it is integrated into a protein complex of the respiratory chain. As the activity of MPP is essential for the viability of eukaryotic cells it is conceivable that inhibitors of MPP which are specific for the soluble enzyme only present in fungi and animals may work as fungicides or insecticides.

Organisationseinheit(en)

Abteilung Pflanzenmolekularbiologie und Pflanzenproteomik

Typ

Artikel

Journal

International Journal of Biochemistry and Cell Biology

Band

29

Seiten

1043-1045

Anzahl der Seiten

3

ISSN

1357-2725

Publikationsdatum

1997

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Biochemie, Zellbiologie

Elektronische Version(en)

https://doi.org/10.1016/S1357-2725(97)00032-0 (Zugang: Unbekannt)