Exploring a potential Achilles heel of Mycobacterium tuberculosis
defining the ClpC1 interactome
- authored by
- David A. Dougan, Regina Alver, Kürşad Turgay
- Abstract
Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb, this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al. performed a bacterial adenylate cyclase two-hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1-interacting proteins. Comment on: doi.org/10.1111/febs.15335.
- Organisation(s)
-
Institute of Microbiology
- External Organisation(s)
-
La Trobe University
Max Planck Unit for the Science of Pathogens (MPUSP)
- Type
- Article
- Journal
- The FEBS journal
- Volume
- 288
- Pages
- 95-98
- No. of pages
- 4
- ISSN
- 1742-464X
- Publication date
- 04.01.2021
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Biochemistry, Molecular Biology, Cell Biology
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Electronic version(s)
-
https://doi.org/10.1111/febs.15430 (Access:
Open)
