Promotion of oxidative phosphorylation by complex I-anchored carbonic anhydrases?

authored by

Hans Peter Braun, Niklas Klusch

Abstract

The mitochondrial NADH-dehydrogenase complex of the respiratory chain, known as complex I, includes a carbonic anhydrase (CA) module attached to its membrane arm on the matrix side in protozoans, algae, and plants. Its physiological role is so far unclear. Recent electron cryo-microscopy (cryo-EM) structures show that the CA module may directly provide protons for translocation across the inner mitochondrial membrane at complex I. CAs can have a central role in adjusting the proton concentration in the mitochondrial matrix. We suggest that CA anchoring in complex I represents the original configuration to secure oxidative phosphorylation (OXPHOS) in the context of early endosymbiosis. After development of ‘modern mitochondria’ with pronounced cristae structures, this anchoring became dispensable, but has been retained in protozoans, algae, and plants.

Organisation(s)

Institute of Plant Genetics

External Organisation(s)

Max Planck Institute of Biophysics

Type

Review article

Journal

Trends in plant science

Volume

29

Pages

64-71

No. of pages

8

ISSN

1360-1385

Publication date

01.2024

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Plant Science

Electronic version(s)

https://doi.org/10.1016/j.tplants.2023.07.007 (Access: Open)
https://doi.org/10.15488/15380 (Access: Open)