Route to novel auxin: auxin chemical space toward biological correlation carriers.

authored by

Thomas Reinard, Noel Ferro, Thomas Bredow

Abstract

The present state of knowledge on structure-activity relationships of auxin-like molecules and their biological repercussion based on different objectives was studied. Auxins act by modulation of multiple proteins rather than the dominant paradigm to act on individual targets. This necessitates characterizing the chemical moieties of auxin-like molecules more deeply by using tools of theoretical and combinatorial chemistry. The first relevant structural rules for auxins stated an auxin molecule requires a ring system as a nucleus, at least one double bond in the ring system, a side chain containing a carboxyl group with at least one atom removed from the ring, and a particular space relationship between the carboxyl group and the ring. It was studied that the action of an auxin consists in a physico-chemical influence of a boundary (PCIB). The existence of more than one receptor in the chain of auxin signal transduction demands the discrimination of the structural-binding relationships for each receptor-ligand pair and evaluation of the physiological relationships for each of them.

Organisation(s)

Section Plant Biotechnology

External Organisation(s)

University of Bonn

Type

Article

Journal

Chemical Reviews

Volume

2010

Pages

4690-4708

ISSN

0009-2665

Publication date

2010

Publication status

Published

Peer reviewed

Yes

Electronic version(s)

https://doi.org/10.1021/cr800229s (Access: Restricted)