Natural product discovery in soil actinomycetes

unlocking their potential within an ecological context

verfasst von

Jana K. Schniete, Lorena T. Fernández-Martínez

Abstract

Natural products (NPs) produced by bacteria, particularly soil actinomycetes, often possess diverse bioactivities and play a crucial role in human health, agriculture, and biotechnology. Soil actinomycete genomes contain a vast number of predicted biosynthetic gene clusters (BGCs) yet to be exploited. Understanding the factors governing NP production in an ecological context and activating cryptic and silent BGCs in soil actinomycetes will provide researchers with a wealth of molecules with potential novel applications. Here, we highlight recent advances in NP discovery strategies employing ecology-inspired approaches and discuss the importance of understanding the environmental signals responsible for activation of NP production, particularly in a soil microbial community context, as well as the challenges that remain.

Organisationseinheit(en)

Institut für Mikrobiologie

Externe Organisation(en)

University of Glasgow

Typ

Übersichtsarbeit

Journal

Current opinion in microbiology

Band

79

Anzahl der Seiten

7

ISSN

1369-5274

Publikationsdatum

06.2024

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Mikrobiologie, Mikrobiologie (medizinisch), Infektionskrankheiten

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1016/j.mib.2024.102487 (Zugang: Offen)